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Pediatrics

Ethnicity Modifies Association Between MicroRNA Single Nucleotide Polymorphisms and Pediatric Acute Lymphoblastic Leukemia Risk: A Meta-Analysis

Strategic Insights

— 1 min read

A recent meta-analysis published in Biomarkers in Medicine has shed light on the relationship between microRNA (miRNA) single nucleotide polymorphisms (SNPs) and pediatric acute lymphoblastic leukemia (ALL) risk. The study, conducted by researchers at the Sri Ramachandra Institute of Higher Education and Research, analyzed 14 studies published between 2001 and 2023 to assess the association between miRNA-SNPs and pediatric ALL risk. The results of the meta-analysis revealed that while pooled data analysis did not show a significant association, a subgroup analysis demonstrated country-specific differences in allele frequencies of the four miRNAs, suggesting ethnicity-based risk.

Key Takeaways:

  • The meta-analysis included 14 studies published between 2001 and 2023 to assess the association between miRNA-SNPs and pediatric ALL risk.
  • The study analyzed miR146 rs2910164, miR-196a2 rs11614913, miR-612 rs12803915, and mir-499 rs3746444 in pediatric ALL patients.
  • Pooled data analysis did not show a significant association between miRNA-SNPs and pediatric ALL risk.
  • A subgroup analysis revealed country-specific differences in allele frequencies of the four miRNAs, suggesting ethnicity-based risk.
  • The study suggests that miRNA-SNPs can still be considered as a potential risk factor to be explored in more populations.
  • The research has been peer-reviewed and published in Biomarkers in Medicine.

Statistics:

  • The meta-analysis included 14 studies published between 2001 and 2023.
  • The study analyzed four miRNAs: miR146 rs2910164, miR-196a2 rs11614913, miR-612 rs12803915, and mir-499 rs3746444.
  • The pooled odds ratio (OR) for the association between miRNA-SNPs and pediatric ALL risk was calculated using MetaGenyo software.
  • The 95% confidence interval (CI) for the pooled OR was not provided in the study.
  • The study suggests that ethnicity-based risk may play a role in the association between miRNA-SNPs and pediatric ALL risk.

Sources:

  • NewsRx. Sri Ramachandra Institute of Higher Education and Research Reports Findings in Acute Lymphoblastic Leukemia (Ethnicity modifies the association between microRNA single nucleotide polymorphisms and pediatric acute lymphoblastic leukemia risk: a ...). Pediatrics Week. June 14, 2025; p 604.
  • Biomarkers in Medicine. Ethnicity modifies the association between microRNA single nucleotide polymorphisms and pediatric acute lymphoblastic leukemia risk: a meta-analysis. 2025:1-15.

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