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Cancer

Gastric Cancer Biomarkers Identified in Peripheral Blood

Strategic Insights

— 1 min read

Gastric cancer remains one of the most common and deadly cancer types worldwide. Researchers from the Federal University of Sao Paulo have identified two minimally invasive biomarkers in peripheral blood that can be used for gastric cancer detection and postoperative monitoring. The study, published in In Vivo, found that expression levels of and mRNA were significantly elevated in patients with gastric cancer compared to healthy individuals.

Key Takeaways:

  • The research explored the potential of and mRNA levels in peripheral blood samples as minimally invasive biomarkers for gastric cancer detection.
  • The study analyzed blood samples from 42 patients with gastric cancer and 12 individuals with no cancer diagnosis, finding elevated expression in patients compared to controls.
  • The results suggest that peripheral blood-based expression can be used as a minimally invasive biomarker for gastric cancer detection and postoperative monitoring.
  • The study highlights the importance of developing minimally invasive diagnostic tools for gastric cancer, which is a significant public health concern worldwide.
  • The authors of the study, including Yeda Beatriz Louredo Santos, Daniel Soares Queiroz, and Leonardo Caires Santos, acknowledge the potential of biomarkers like and for improving patient outcomes.
  • The study's findings have potential implications for the development of new diagnostic and therapeutic strategies for gastric cancer.

Statistics:

  • The study analyzed blood samples from 42 patients with gastric cancer and 12 individuals with no cancer diagnosis.
  • The researchers found that expression levels of and mRNA were significantly elevated in patients with gastric cancer compared to healthy individuals.
  • The study used a minimally invasive approach to detect gastric cancer, which could improve patient outcomes and reduce the risk of complications.
  • Gastric cancer is one of the most common and deadly cancer types worldwide, with a significant public health impact.

Sources:

  • Peripheral Blood-based NRN1 and TNFAIP3 Gene Expression as Minimally Invasive Biomarkers for Gastric Cancer. In Vivo, 2025;39(5):2646-2658.
  • NewsRx. Study Data from Federal University of Sao Paulo Update Understanding of Gastric Cancer (Peripheral Blood-based NRN1 and TNFAIP3 Gene Expression as Minimally Invasive Biomarkers for Gastric Cancer). Cancer Weekly. September 16, 2025; p 3757.

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