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Cancer

Gastric Cancer Prognosis Improved with Novel Immune-Inflammatory-Nutritional-Tumor Marker (IINTM) Score

Strategic Insights

— 1 min read

Researchers at the First Affiliated Hospital of Air Force Medical University in Shaanxi, People's Republic of China, have developed a new scoring system to help predict the prognosis of gastric cancer patients. The Immune-Inflammatory-Nutritional-Tumor Marker (IINTM) score combines several indices, including the Prognostic Nutritional Index (PNI) and Systemic Immune-Inflammation Index (SII), to forecast the risk of malignant cachexia, a debilitating condition that often leads to a poor prognosis. The study analyzed data from 1,101 gastric cancer patients and found that the IINTM score had a high concordance index (C-index) of 0.784, indicating its robust predictive efficacy.

Key Takeaways:

  • The IINTM score combines 10 indices, including PNI, SII, body mass index (BMI), NRS2002, serum albumin, platelet, D-dimer, CEA, and CA199, to predict gastric cancer prognosis.
  • Patients with gastric cancer and cachexia had worse prognoses and lower skeletal muscle mass scores than those without cachexia.
  • The IINTM score demonstrated substantial diagnostic value for cachexia, with an area under the receiver operating characteristic (AUC) of 0.858.
  • The study highlights the importance of early diagnosis and timely prediction of survival outcomes for gastric cancer patients.
  • The IINTM score could be a reliable tool for clinicians to predict the risk of cachexia and prognosis in gastric cancer patients.

Statistics:

  • 1,101 gastric cancer patients were included in the study.
  • The IINTM score had a high concordance index (C-index) of 0.784.
  • The AUC for diagnose cachexia was 0.858.
  • Patients with cachexia had lower skeletal muscle mass scores than those without cachexia.
  • The study found significant associations between prognosis and nutritional indices, including PNI and SII.

Sources:

  • "Prognostic value of combining preoperative immune-inflammatory-nutritional index and tumor biomarkers in gastric cancer patients undergoing radical resection." Frontiers in Nutrition, 2025,12. (Frontiers in Nutrition - http://www.frontiersin.org/nutrition).
  • (10.3389/fnut.2025.1562202)

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