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Cancer research

Gastric Cancer Research Reveals Impact of Antiplatelet Drugs on Ulcer Healing

Strategic Insights

— 1 min read

New research in the Second Department of Internal Medicine has investigated the effects of antiplatelet drugs on gastric ulcer healing after endoscopic submucosal dissection (ESD) for early gastric cancer. The study, which included 170 lesions from 149 patients, found that antiplatelet drugs, particularly clopidogrel, may delay gastric ulcer healing. The research highlights the need for careful endoscopic follow-up and drug therapy for patients taking antiplatelet drugs.

Key Takeaways:

  • The study found that antiplatelet drugs, including clopidogrel, may delay gastric ulcer healing after ESD for early gastric cancer.
  • The ulcer reduction ratio for clopidogrel on the 28th day after ESD was significantly lower than the ulcer reduction ratio for no drug.
  • The study identified four independent risk factors for delayed ulcer healing: antiplatelet drugs, ulcer size of 40 mm on the first day, hemoglobin A1c 6.5%, and age of 75.
  • The study suggests that careful endoscopic follow-up and drug therapy are necessary for patients taking antiplatelet drugs.

Statistics:

  • 170 lesions from 149 patients were included in the study.
  • 92.8% of patients without antiplatelet drugs experienced ulcer reduction on the 28th day after ESD, compared to 84.8% of patients taking clopidogrel.
  • The odds ratio (OR) for delayed ulcer healing was 3.905 for antiplatelet drugs (p = 0.017).
  • The OR for delayed ulcer healing was 4.903 for ulcer size of 40 mm on the first day (p = 0.006).
  • The OR for delayed ulcer healing was 7.659 for hemoglobin A1c 6.5% (p = 0.012).
  • The OR for delayed ulcer healing was 5.227 for age of 75 (p = 0.007).

Sources:

  • NewsRx. Reports from Second Department of Internal Medicine Highlight Recent Research in Gastric Cancer (Influence of antiplatelet drugs on gastric ulcer healing after endoscopic submucosal dissection in patients with early gastric cancer). Health & Medicine Week. May 16, 2025; p 4923.
  • Influence of antiplatelet drugs on gastric ulcer healing after endoscopic submucosal dissection in patients with early gastric cancer. DEN Open, 2025,5(1):n/a-n/a.

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