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Cancer

Gastric Cancer Study Reveals Predictive Factors for Lymph Node Metastasis

Strategic Insights

— 1 min read

Research conducted at Sichuan Integrative Medicine Hospital in Chengdu, People's Republic of China, has explored the predictive value of certain detection indexes and pathological serum levels in patients with early gastric cancer who underwent radical surgery. The study retrospectively analyzed clinical data of 297 EGC patients admitted to the hospital from March 2019 to March 2024. The findings indicate that clinically relevant detection indexes and pathological P53 levels can predict the occurrence of lymph node metastasis (LNM) after EGC radical surgery, which can assist in formulating scientific and reasonable clinical treatment plans.

Key Takeaways:

  • The study analyzed 297 EGC patients who underwent radical gastrectomy for gastric cancer.
  • The average number of lymph nodes detected in the LNM (-) group was 28.35 ± 8.23, which was lower than in the LNM (+) group (33 ± 15), indicating a significant difference in lymph node count between the two groups.
  • The predictive factors, including serum NLR, PLR, P53, and K67 levels, had a good predictive effect on the occurrence of LNM in patients after EGC radical surgery.
  • Li Feifei, Shi Yingxi, Wang Zhaojun, and Wang Ying were among the authors contributing to this research.
  • The study's results suggest that a combination of clinical data and pathological analysis can assist clinicians in making informed decisions about treatment plans.

Statistics:

  • 297 EGC patients were included in the study.
  • 43 cases (14.48%) of postoperative LNM were detected among the 297 EGC patients.
  • The average number of lymph nodes detected in the LNM (-) group was 28.35 ± 8.23.
  • The LNM (+) group had an average of 33 ± 15 lymph nodes detected.
  • The predictive factors had a significant predictive effect, with a p-value indicating statistical significance.

Sources:

  • Prognostic value of serum NLR, PLR, P53, K67 level in lymph node metastasis of early gastric cancer. Journal of Medical Biochemistry, 2025,44(4):792-800.
  • Department of Medical Oncology, Sichuan Integrative Medicine Hospital, Chengdu, People's Republic of China.

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