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Cancer

Gastric Cancer Treatment: Laparoscopic versus Open Gastrectomy Study Published

Strategic Insights

— 1 min read

Researchers have published the results of a study comparing the effectiveness of laparoscopic and open gastrectomy in treating gastric cancer. The trial aimed to determine whether laparoscopic distal gastrectomy (LDG) is non-inferior to open distal gastrectomy (ODG) in terms of disease-free survival and other outcomes. The study involved 240 patients with resectable T4a gastric cancer, who were randomly assigned to either LDG or ODG. The results will provide evidence to inform future guidelines and clinical decision-making in the management of T4a gastric cancer.

Key Takeaways:

  • The study aimed to compare the short- and long-term outcomes of LDG and ODG in resectable T4a GC.
  • The trial involved 240 patients (120 each group) and was designed to show non-inferiority of LDG with respect to the primary end-point, 3-years disease-free survival (DFS).
  • Secondary endpoints included morbidity, mortality, postoperative recovery, and quality of life.
  • The study is the first prospective randomized trial specifically designed to compare laparoscopic and open approaches for T4a GC.
  • Tran Quang Dat and colleagues from the University Medical Center conducted the research.

Statistics:

  • 240 patients were required to statistically show non-inferiority of LDG with respect to the primary end-point, 3-years disease-free survival (DFS).
  • The trial aimed to standardize surgical techniques and ensure experienced surgeons perform the procedures.
  • ClinicalTrials.gov registration number: NCT04384757.
  • 08/05/2020: Registration Date.
  • The study involved 120 patients in each group (LDG and ODG).

Sources:

  • Laparoscopic versus open distal gastrectomy with d2 lymphadenectomy in treatment of locally T4A gastric cancer: the protocol of a randomized controlled trial. BMC Surgery, 2025,25(1):1-11.
  • BMC Surgery - http://bmcsurg.biomedcentral.com
  • A free version of this journal article is available at https://doi-org.sdpl.idm.oclc.org/10.1186/s12893-025-02933-6.

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