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Gastroenterology Study Reveals Insights into Radioembolization Effects on Liver Tissue

Strategic Insights

— 1 min read

Researchers from the University Medical Center Utrecht conducted a study to investigate the effect of radiation on liver tissue in patients with colorectal liver metastases. The study aimed to evaluate changes in standardized uptake values (SUV) in treated and untreated non-tumorous liver tissue after unilobar radioembolization. The study included 18 patients who underwent radioembolization with 90Y-glass microspheres. The results showed no significant increase in SUV in treated and untreated non-tumorous liver tissue three months after radioembolization. The study concluded that non-tumorous liver tissue can serve as a reliable reference measure for assessing metabolic response after radioembolization.

Key Takeaways:

  • The study included 18 patients with colorectal liver metastases who underwent unilobar radioembolization with 90Y-glass microspheres.
  • The median mean standardized uptake value corrected for lean body mass in treated and untreated liver tissue increased and decreased, respectively, after treatment, but the change was not significant.
  • The study found no correlation between [18F]FDG-uptake and treated or untreated non-tumorous liver absorbed dose.
  • No significant trend was seen between [18F]FDG-uptake and treated or untreated non-tumorous liver absorbed dose.
  • The study concluded that non-tumorous liver tissue can serve as a reliable reference measure for assessing metabolic response after radioembolization.
  • The study was published in the EJNMMI Research journal, 2025, 15(1):1-8.

Statistics:

  • 18 patients were included in the study.
  • The median mean standardized uptake value corrected for lean body mass in the treated lobe increased from 2.88 to 2.98 after treatment.
  • The median mean standardized uptake value corrected for lean body mass in the untreated lobe decreased from 2.95 to 2.88 after treatment.
  • The correlation for the ratio of treated/untreated liver changed from 0.96 to 1.00 after treatment (p = 0.147).

Sources:

  • Can non-tumorous liver tissue serve as a reliable reference measure for [18F]FDG-PET-CT after unilobar 90Y glass radioembolization in patients with colorectal liver metastases?. EJNMMI Research, 2025,15(1):1-8. (EJNMMI Research - http://www.ejnmmires.com/)
  • Studies in the Area of Gastroenterology Reported from University Medical Center Utrecht (Can non-tumorous liver tissue serve as a reliable reference measure for [18F]FDG-PET-CT after unilobar 90Y glass radioembolization in patients with ...). Gastroenterology Week. October 20, 2025; p 1407.

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