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Genetic research

Genomic Analysis Reveals Promising Probiotic Strains for Aquaculture

Strategic Insights

— 1 min read

Research at Don State Technical University in Rostov on Don, Russia, has shed light on the genomic characteristics and bioactive metabolite profiles of three novel strains isolated from the intestinal tracts of healthy carp. The study, which has been peer-reviewed, identified the strains as belonging to the Bacillus genus and revealed a repertoire of secondary metabolites, including bacillaene, bacillibactin, bacilysin, difficidin, and fengycin, which are likely to contribute to the probiotic potential of these strains. The researchers also isolated and identified fengycins and bacillibactin using matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) mass spectrometry.

Key Takeaways:

  • The study identified three novel strains isolated from the intestinal tracts of healthy carp, which were classified as Bacillus spp. (R1 and R4) and Bacillus sp. (R5).
  • Genome mining revealed a repertoire of secondary metabolites, including bacillaene, bacillibactin, bacilysin, difficidin, and fengycin, which are likely to contribute to the probiotic potential of these strains.
  • The researchers isolated and identified fengycins and bacillibactin using MALDI-TOF mass spectrometry.
  • The study assessed the presence of genetic markers associated with antimicrobial resistance and reconstructed the gene profiles.
  • The strains represent promising candidates for the development of novel feed additives for aquaculture.

Statistics:

  • The study identified 5 secondary metabolites in the three novel strains, including bacillaene, bacillibactin, bacilysin, difficidin, and fengycin.
  • MALDI-TOF mass spectrometry was used to isolate and identify fengycins and bacillibactin.
  • The study assessed genetic markers associated with antimicrobial resistance in the three novel strains.
  • The research concluded that the strains represent promising candidates for the development of novel feed additives for aquaculture.

Sources:

  • "Genomic Analysis and Metabolite Profiling of Three Probiotic Bacillus Strains for Potential Application in Aquaculture." Preventive Nutrition and Food Science, 2025;30(3):274-284.
  • NewsRx LLC, "Don State Technical University Reports Findings in Food Science and Preventive Nutrition (Genomic Analysis and Metabolite Profiling of Three Probiotic Bacillus Strains for Potential Application in Aquaculture)". Food Weekly News, July 17, 2025; p 54.

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