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Nanotechnology

Gentamicin Determination Using Silver Nanoparticles and Smartphone-based Detection

Strategic Insights

— 1 min read

Researchers from Jagiellonian University in Krakow, Poland, have developed a novel method for determining gentamicin using silver nanoparticles (AgNPs) and smartphone-based detection. This method utilizes a natural stabilising and reducing agent, gallic acid, to synthesize AgNPs and induce aggregation in the presence of gentamicin. The study demonstrated the analytical parameters of the developed method, including the linear range, limit of quantification, and precision, making it a potential alternative to other methods reported in the literature.

Key Takeaways:

  • The researchers developed a gentamicin determination method using silver nanoparticles (AgNPs) and smartphone-based detection, which has potential as an alternative to other methods.
  • The method utilizes gallic acid as a natural stabilising and reducing agent for AgNPs synthesis and gentamicin-induced aggregation.
  • The study demonstrated the analytical parameters of the developed method, including a linear range of 30.00-90.00 μg dm-3, a limit of quantification of 30.00 μg dm-3, and precision (CV, n = 6) of 6.5 and 2.6% for spectrophotometric and smartphone-based detection methods, respectively.
  • The selectivity of AgNPs under selected conditions against other antibiotics was examined, and the method was successfully applied to determine gentamicin in eye drop samples.
  • The researchers utilized compact and accessible equipment, which made the method feasible for use in various settings.
  • The study was peer-reviewed and funded by Narodowym Centrum Nauki, Faculty of Chemistry under the Strategic Programme Excellence Initiative at Jagiellonian University - National Science Centre, Poland, and Marie Curie Actions.

Statistics:

  • Linear range: 30.00-90.00 μg dm-3
  • Limit of quantification: 30.00 μg dm-3
  • Precision (CV, n = 6) for spectrophotometric detection: 6.5%
  • Precision (CV, n = 6) for smartphone-based detection: 2.6%
  • Selectivity of AgNPs against other antibiotics: examined under selected conditions

Sources:

  • Monatshefte fur Chemie - Chemical Monthly, 2025
  • Springer Wien, Prinz-Eugen-Strasse 8-10, A-1040 Vienna, Austria
  • NewsRx. New Findings from Jagiellonian University Update Understanding of Nanoparticles (Gentamicin Determination Using Silver Nanoparticles and Smartphone-based Detection). Nanotechnology Weekly. October 27, 2025; p 652

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