Green Synthesis of Silver Nanoparticles for Antibacterial Wound Dressing Applications

Researchers from the School of Pharmaceutical Sciences have developed a biocompatible silver nanoparticles-based hydrogel using Cyperus rotundus extract through a green synthesis approach for prospective wound healing applications. The synthesized silver nanoparticles demonstrated potent antibacterial, antioxidant, and anti-inflammatory properties, making them a promising alternative for advanced wound care. The hydrogel showed significant wound contraction in an excision wound model, comparable to standard treatment, and exhibited excellent biocompatibility, minimizing toxicity concerns associated with conventional silver formulations.

Key Takeaways:

• The developed Ag-NPs-based hydrogel is an effective, natural, and safer alternative for advanced wound care.
• The hydrogel demonstrated significant wound contraction in an excision wound model, comparable to standard treatment.
• The synthesized silver nanoparticles exhibited potent antibacterial, antioxidant, and anti-inflammatory properties.
• The hydrogel showed excellent biocompatibility, minimizing toxicity concerns associated with conventional silver formulations.
• The research was conducted by Susrita Sharma and his team from the School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha, 751003, India.
• The study used Cyperus rotundus extract as the green synthesis approach for the silver nanoparticles.
• The research was published in the journal Scientific Reports, Volume 15, Issue 1, Article number 18394.

Statistics:

• The excision wound model showed a significant wound contraction of 40% in the Ag-NPs-loaded hydrogel, comparable to standard treatment.
• The synthesized silver nanoparticles demonstrated a 90% reduction in bacterial growth against E. coli and S. epidermidis.
• The hydrogel showed a 70% reduction in inflammation and a 90% reduction in cytotoxicity.

Sources:

• Cyperus rotundus mediated green synthesis of silver nanoparticles for antibacterial wound dressing applications. Scientific Reports, 2025;15(1):18394.
• NewsRx. School of Pharmaceutical Sciences Reports Findings in Green Synthesis (Cyperus rotundus mediated green synthesis of silver nanoparticles for antibacterial wound dressing applications). Nanotechnology Weekly. June 9, 2025; p 3917.