Green Synthesis of Silver Nanoparticles Using Passiflora Subpeltata for Multiple Applications

Researchers from Periyar University in India have successfully synthesized silver nanoparticles using the aqueous extract of Passiflora subpeltata, a plant rich in secondary metabolites. These nanoparticles have shown promising results in antibacterial, antioxidant, anti-cancer, and larvicidal activities, making them a potential candidate for various biomedical applications. The study highlights the potential of green synthesis of nanoparticles using plant extracts, providing a sustainable and environmentally friendly alternative to traditional methods.

Key Takeaways:

• The study demonstrated the green synthesis of silver nanoparticles using Passiflora subpeltata aqueous extract as the reducing and stabilizing agent.
• The nanoparticles showed absorption peak at 456 nm, crystalline nature, and predominantly spherical shape.
• The antibacterial activity of P-S-AgNPs was observed against B. cereus, with a zone of inhibition of 27 mm at a higher dose of 75 μg/mL.
• The antioxidant activity was tested against DPPH, ABTS, and H2O2 assays, with the best scavenging activity observed in DPPH with an IC50 value of 108.92 μg/mL.
• The anti-proliferative activity in human colon cancer cell-line (HT-29) indicated significant results with an IC50 value of 33.05 μg/mL.
• The larvicidal activity of PS-AgNPs showed good activity against Cx. quinquefasicatus larvae, with LC50 and LC90 values of 4.99 and 22.19 units, respectively.
• The study concluded that the green synthesized NPs could be a potential candidate for various biomedical applications.

Statistics:

• 456 nm: Absorption peak of Ps-AgNPs.
• 27 mm: Zone of inhibition of bacteria B. cereus.
• 108.92 μg/mL: IC50 value of DPPH scavenging activity.
• 33.05 μg/mL: IC50 value of anti-proliferative activity in HT-29 cell-line.
• 4.99 units: LC50 value of PS-AgNPs against Cx. quinquefasicatus larvae.
• 22.19 units: LC90 value of PS-AgNPs against Cx. quinquefasicatus larvae.

Sources:

• Biological Synthesis and Characterization of Passiflora Subpeltata Ortega Aqueous Leaf Extract In Silver Nanoparticles and Their Evaluation of Antibacterial, Antioxidant, Anti-cancer and Larvicidal Activities. Journal of King Saud University - Science, 2022;34(3).
• NewsRx. New Nanoparticles Findings from Periyar University Discussed (Biological Synthesis and Characterization of Passiflora Subpeltata Ortega Aqueous Leaf Extract In Silver Nanoparticles and Their Evaluation of Antibacterial, Antioxidant, Anti-cancer ...). Biotech Week. April 6, 2022; p 808.