Insulin-Dependent Diabetes Mellitus in Mice Does Not Alter Liver Heparan Sulfate

A recent study published in the Journal of Biological Chemistry has provided new insights into the relationship between insulin-dependent diabetes mellitus and liver heparan sulfate in mice. The researchers, from the University of California, La Jolla, found that despite fasting hypertriglyceridemia and delayed clearance of dietary triglyceride-rich lipoproteins in diabetic mice, there were no significant differences in liver heparan sulfate content, sulfation, syndecan-1 protein levels, or affinity for heparin-binding ligands. This suggests that hyperlipidemia in insulin-deficient mice is not due to changes in hepatic heparan sulfate composition.

Key Takeaways:

• Researchers from the University of California, La Jolla, conducted a study on insulin-dependent diabetes mellitus in mice and its effects on liver heparan sulfate.
• Despite fasting hypertriglyceridemia and delayed clearance of dietary triglyceride-rich lipoproteins in diabetic mice, there were no significant differences in liver heparan sulfate content, sulfation, syndecan-1 protein levels, or affinity for heparin-binding ligands.
• The study found decreased incorporation of [(35)S]sulfate in insulin-deficient mice in vivo, but the decrease was due to increased plasma inorganic sulfate, which reduced the efficiency of labeling of liver heparan sulfate.
• The researchers concluded that hyperlipidemia in insulin-deficient mice is not due to changes in hepatic heparan sulfate composition.
• The study was published in the Journal of Biological Chemistry in 2010.

Statistics:

• The study found that diabetic mice displayed fasting hypertriglyceridemia and delayed clearance of dietary triglyceride-rich lipoproteins.
• There were no significant differences in liver heparan sulfate content, sulfation, syndecan-1 protein levels, or affinity for heparin-binding ligands between normal and diabetic littermates.
• The decreased incorporation of [(35)S]sulfate in insulin-deficient mice in vivo was observed, but the decrease was due to increased plasma inorganic sulfate (2010).

Sources:

• Bishop, J. R., et al. (2010). Insulin-dependent diabetes mellitus in mice does not alter liver heparan sulfate. Journal of Biological Chemistry, 285(19), 14658-14662.
• This article was prepared by Science Letter editors from staff and other reports. Copyright 2011, Science Letter via NewsRx.com.