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Cancer

Intravenous Thrombolysis for Pediatric Ischemic Stroke Secondary to Cancer Therapy-Related Cardiac Dysfunction

Strategic Insights

— 1 min read

Research published in Internal Medicine journal revealed a case of an 11-year-old boy who developed cardioembolic stroke (CES) and cancer therapy-related cardiac dysfunction (CTRCD) despite effective treatment with high-dose chemotherapy. The patient was admitted with severe aphasia and magnetic resonance imaging showed occlusion of the left middle cerebral artery M3 segment. After administering intravenous thrombolysis, the patient achieved effective recanalization and had no neurological deficits during discharge. This case highlights the effectiveness of reperfusion therapy for pediatric patients with CES secondary to CTRCD.

Key Takeaways:

  • An 11-year-old boy developed cardioembolic stroke (CES) and cancer therapy-related cardiac dysfunction (CTRCD) after treatment with high-dose chemotherapy.
  • The patient was admitted with severe aphasia and magnetic resonance imaging showed occlusion of the left middle cerebral artery M3 segment.
  • Intravenous thrombolysis was administered, resulting in effective recanalization and no neurological deficits during discharge.
  • Reperfusion therapy for pediatric patients has not yet been established, but this case suggests it may be effective for CES secondary to CTRCD.
  • The patient's treatment by Tomohisa Nezu and colleagues at Hiroshima University involved a multidisciplinary approach, including hematology, oncology, and cardiology experts.
  • This case study contributes to the growing understanding of stroke-related complications in pediatric cancer patients and the need for specialized treatment approaches.

Statistics:

  • Age of the patient: 11 years
  • Number of days in hospital: Not specified
  • Number of patients studied: 1 (case study)
  • Frequency of CES secondary to CTRCD in pediatric patients: Not specified
  • Effectiveness of intravenous thrombolysis in this patient: 100% recanalization with no neurological deficits

Sources:

  • "Intravenous Thrombolysis for Pediatric Ischemic Stroke Secondary To Cancer Therapy-related Cardiac Dysfunction" by Nezu et al. published in Internal Medicine, 2025;64(2):287-291.
  • Japan Soc Internal Medicine, 34-3 3-Chome Hongo Bunkyo-Ku, Tokyo, 113, Japan (publisher of Internal Medicine journal).
  • NewsRx. Reports on Stroke from Hiroshima University Provide New Insights (Intravenous Thrombolysis for Pediatric Ischemic Stroke Secondary To Cancer Therapy-related Cardiac Dysfunction). Hematology Week. May 12, 2025; p 424.

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