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Investigating Urticaria: New Insights from Ankara University Faculty of Medicine

Strategic Insights

— 1 min read

A recent study published in the Ankara Universitesi Tip Fakultesi Mecmuas journal sheds light on the role of leukocytes in allergic reactions, specifically in cases of urticaria and anaphylaxis. Researchers from Ankara University Faculty of Medicine conducted a retrospective analysis of blood leukocyte counts and ratios in patients with drug-induced urticaria-angioedema, drug/venom-triggered anaphylaxis, and healthy controls. The study revealed that neutrophil-lymphocyte ratio (NLR) was significantly higher in patients with urticaria-angioedema and anaphylaxis compared to controls.

Key Takeaways:

  • Researchers found that neutrophil-lymphocyte ratio (NLR) was significantly higher in patients with urticaria-angioedema (2.09) and anaphylaxis (1.905) compared to controls (1.815).
  • NLR was notably elevated in patients with urticaria-angioedema, suggesting a possible association with the severity of allergic reactions.
  • No significant differences in NLR were found between the urticaria-angioedema and anaphylaxis groups.
  • Leukocyte ratios other than NLR showed no significant changes between patient and control groups.
  • The study concluded that NLR may indicate allergic responses but lacks predictive value for reaction type or severity.
  • 100 patients with drug-induced urticaria-angioedema, 100 patients with drug/venom-triggered anaphylaxis, and 100 healthy controls were included in the study.
  • Median NLR was 1.975 in patients and 1.815 in controls.
  • The study was conducted by Alper Ekinci and Seda Altiner from Ankara University Faculty of Medicine.

Statistics:

  • Neutrophil-lymphocyte ratio (NLR) in patients with urticaria-angioedema: 2.09
  • NLR in patients with anaphylaxis: 1.905
  • NLR in controls: 1.815
  • Significance of NLR in patients with urticaria-angioedema: p=0.008
  • Significance of NLR in patients with anaphylaxis: p=0.038
  • Significance of NLR differences between urticaria-angioedema and anaphylaxis groups: p=0.09
  • Significance of NLR differences between anaphylaxis and control groups: p=0.342
  • Number of patients included in the study: 300

Sources:

  • Ankara Universitesi Tip Fakultesi Mecmuas, 2025, 78(1):13-19. doi: 10.4274/atfm.galenos.2025.62593
  • NewsRx. Study Findings from Ankara University Faculty of Medicine Advance Knowledge in Urticaria (Blood Leukocyte Ratios: Equivocal Parameters for Allergic Diseases). Health & Medicine Week. August 8, 2025; p 5343.

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