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Microbiota (Symbiotic organisms)

LGG/LAC-MMT Combination Mitigates AFB1-Induced Liver and Intestinal Injury in Mice

Strategic Insights

— 1 min read

Research published in the Frontiers in Veterinary Science journal has revealed that a combination of Lactobacillus acidophilus (LAC), Lactobacillus rhamnosus (LGG), and Montmorillonite (MMT) can effectively alleviate tissue damage caused by AFB1 exposure and enhance LAB colonization capacity in mouse intestines. According to the study, the combination of LGG, LAC, and MMT supplementation restored oxidative stress and inflammatory caused by AFB1 to some degree, altered the intestinal microbiota structure, and enhanced the colonization ability of LABs.

Key Takeaways:

  • The LGG/LAC-MMT combination can mitigate AFB1-induced liver and intestinal injury in mice based on intestinal microbiota modulation.
  • Lactobacillus acidophilus (LAC) and Lactobacillus rhamnosus (LGG) have strong binding affinity for AFB1 and can adsorb it, thereby reducing its toxicity.
  • Montmorillonite (MMT) serves as a carrier for LAB and enhances their colonization ability and prolongs their survival.
  • The combination of LGG, LAC, and MMT supplementation restored oxidative stress and inflammatory caused by AFB1 to some degree.
  • The LGG/LAC-MMT combination altered the intestinal microbiota structure, enhancing the colonization ability of LABs, thereby alleviating liver and intestinal injury.
  • The study aimed to determine whether the LGG/LAC-MMT combination could effectively alleviate tissue damage from AFB1 exposure and enhance LAB colonization capacity in mouse intestines.
  • The research was conducted at Heilongjiang Bayi Agricultural University, Daqing, People's Republic of China.

Statistics:

  • The study involved a total of 40 mice divided into four groups: control mice, AFB1-intoxicated mice, mice treated with LGG (2 x 10^9 cfu/mL) and LAC (2 x 10^9 cfu/mL), and mice treated with LGG/LAC-MMT combination.
  • The mice were gavaged with the mixtures for 4 weeks.
  • The results showed that the LGG/LAC-MMT combination restored oxidative stress and inflammatory caused by AFB1 to some degree (p < 0.05).
  • The intestinal microbiota structure was altered, and the colonization ability of LABs was enhanced.
  • The study concluded that the combination of LGG/LAC-MMT was more effective in mitigating AFB1-induced liver and intestinal injury.

Sources:

  • LGG/LAC-MMT combination mitigates AFB1-induced liver and intestinal injury in mice based on intestinal microbiota modulation. Frontiers in Veterinary Science, 2025,12. (Frontiers in Veterinary Science - http://www.frontiersin.org/Veterinary_Science).
  • Jiaxin Cheng, Ying Gao, Hongming Lv, Jing Li, Xudong Sun, Tianhui An, Honglin Liu, Junqi Wang, Haifeng Zhang, Haiyan Wang, Siqi Zou, Zhao Fan, Yuanyuan Chen. Heilongjiang Bayi Agricultural University, Daqing High-Tech Industrial Development Zone, Daqing, People's Republic of China.

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