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Coronaviruses

Manufacturing a Chimpanzee Adenovirus-Vectored SARS-CoV-2 Vaccine to Meet Global Needs

Strategic Insights

— 1 min read

Researchers at the University of Oxford have developed a novel manufacturing process for the production of the ChAdOx1 nCoV-19 vaccine, which has been instrumental in meeting global COVID-19 vaccine demands. The vaccine, also known as AZD1222 or Vaxzevria, has been proven to be efficacious against SARS-CoV-2, a virus responsible for the COVID-19 pandemic. The team's innovative approach has enabled the largest viral vector manufacturing campaign to date, providing a substantial proportion of global COVID-19 vaccine supply at a low cost.

Key Takeaways:

  • The ChAdOx1 nCoV-19 vaccine was developed by the University of Oxford's Jenner Institute and has been shown to be efficacious against SARS-CoV-2.
  • The vaccine was manufactured using a novel process, which included novel features to facilitate very large-scale production.
  • The "distributed manufacturing" approach taken by the researchers enabled the production of the vaccine at globally-relevant scale and with international security of supply.
  • The development of this vaccine was supported by funding from AstraZeneca, the UK Department for Business, Energy and Industrial Strategy, the Engineering & Physical Sciences Research Council (EPSRC), and UK Research and Innovation.
  • The research was conducted by a team of researchers from the University of Oxford, including Alexander D. Douglas, Carina C. D. Joe, and Yuanyuan Li, among others.
  • The study's findings were published in the Biotechnology and Bioengineering journal in 2021.

Statistics:

  • The vaccine production process enabled the largest viral vector manufacturing campaign to date.
  • The vaccine was produced at a low cost, meeting global COVID-19 vaccine demands.
  • The study was funded by multiple organizations, including AstraZeneca.
  • The research was published in the Biotechnology and Bioengineering journal, which is published by Wiley.

Sources:

  • NewsRx. New COVID-19 Study Findings Reported from University of Oxford (Manufacturing a Chimpanzee Adenovirus-vectored Sars-cov-2 Vaccine To Meet Global Needs). Vaccine Weekly. December 15, 2021; p 540.
  • Biotechnology and Bioengineering. Manufacturing a Chimpanzee Adenovirus-vectored Sars-cov-2 Vaccine To Meet Global Needs (2021).
  • University of Oxford, Jenner Institute. Manufacturing a Chimpanzee Adenovirus-vectored Sars-cov-2 Vaccine To Meet Global Needs.

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