Sign in Subscribe
Diseases

Mitochondria Play Crucial Role in Rheumatoid Arthritis Development and Progression

Strategic Insights

— 1 min read

Recent research conducted at the University of Messina has highlighted the significance of mitochondria in the onset and progression of rheumatoid arthritis (RA). The study, published in Biomedicines, discusses the role of mitochondria in the physiopathology of RA, contributing to chronic inflammation, cartilage and bone injury, and chronic autoimmune response. The research emphasizes the importance of mitochondrial activity in influencing various aspects of the disease, including mitochondrial dynamics, bone homeostasis, DAMPs, and immune cell functionality.

Key Takeaways:

  • Mitochondria play a crucial role in the physiopathology of rheumatoid arthritis, contributing to chronic inflammation, cartilage and bone injury, and chronic autoimmune response.
  • Mitochondrial activity influences many aspects of the disease, including mitochondrial dynamics, bone homeostasis, DAMPs, and immune cell functionality.
  • Recent therapeutic approaches aim to improve mitochondrial function, reduce oxidative stress, modulate mitochondria-mediated inflammation, and restore energy metabolism homeostasis.
  • The University of Messina's research suggests that targeting mitochondria could be a novel approach in the fight against RA.
  • Antonella Iaconis, Francesco Molinari, and Roberta Fusco were among the researchers who contributed to this study.
  • The study was published in Biomedicines, a journal published by MDPI AG.

Statistics:

  • According to the Biomedicines journal, the study "Mitochondria as a Disease-Relevant Organelle in Rheumatoid Arthritis: A Key Breakout in Fight Against the Disease" was published in 2025, volume 13, issue 7, page 1708.
  • The study was conducted at the Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm) of the University of Messina, Italy.
  • Affiliation of researchers: Antonella Iaconis and Francesco Molinari (Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina), Roberta Fusco (Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina).

Sources:

  • NewsRx. Data from University of Messina Broaden Understanding of Rheumatoid Arthritis (Mitochondria as a Disease-Relevant Organelle in Rheumatoid Arthritis: A Key Breakout in Fight Against the Disease). Health & Medicine Week. August 15, 2025; p 571.
  • Biomedicines, 2025,13(7):1708. (Biomedicines - http://www.mdpi.com/journal/biomedicines)
  • Antonella Iaconis, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.

Read more