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Nuclear energy

Mitochondria-Targeted Long-Wavelength Fluorescent Probe for Imaging Sulfur Dioxide in Ferroptosis

Strategic Insights

— 1 min read

Ferroptosis, a type of programmed cell death, is a crucial factor in the pathogenesis of numerous diseases. Mitochondria play a significant role in this process, and abnormal levels of sulfur dioxide (SO) in the mitochondria are linked to mitochondrial dysfunction and various diseases. Researchers at the China Institute of Atomic Energy have developed a novel, long-wavelength fluorescent probe called CMP that enables real-time imaging of sulfur dioxide in the mitochondria. This breakthrough offers a valuable tool for studying ferroptosis-related diseases.

Key Takeaways:

  • The researchers developed a mitochondria-targeted long-wavelength fluorescent probe called CMP that can detect sulfur dioxide in ferroptosis.
  • CMP utilizes a benzopyrylium cation for HSO recognition and mitochondrial targeting, achieving ultrasensitive detection.
  • CMP enables real-time imaging of sulfur dioxide in HeLa cells and zebrafish, and successfully detects increased mitochondrial HSO levels during Erastin-induced ferroptosis and CCCP-induced apoptosis.
  • The probe offers a valuable tool for studying ferroptosis-related diseases.
  • The research was supported by the Natural Science Foundation of Shandong Province and the China Institute of Atomic Energy.
  • The team consisted of researchers from the China Institute of Atomic Energy, including Yulong Wu, Tianyu Zhang, Guangyi Jiang, Qingxia Duan, Chen Zuo, and Wei Shu.

Statistics:

  • The probe has a high specificity and rapid response.
  • It achieves ultrasensitive detection of sulfur dioxide in the mitochondria.
  • The research has been peer-reviewed.
  • The study was conducted using HeLa cells and zebrafish.
  • The probe can detect increased mitochondrial HSO levels during Erastin-induced ferroptosis and CCCP-induced apoptosis.

Sources:

  • NewsRx. China Institute of Atomic Energy Reports Findings in Chemicals and Chemistry (A mitochondria-targeted long-wavelength fluorescent probe for imaging sulfur dioxide in ferroptosis). Chemicals & Chemistry. June 27, 2025; p 327.
  • A mitochondria-targeted long-wavelength fluorescent probe for imaging sulfur dioxide in ferroptosis. Analytical Methods, 2025.
  • Royal Society of Chemistry. Royal Soc Chemistry, Thomas Graham House, Science Park, Milton Rd, Cambridge CB4 0WF, Cambs, England.
  • Royal Society of Chemistry. www.rsc.org/; Analytical Methods. pubs.rsc.org/en/journals/journalissues/ay
  • NewsRx LLC. 2025.

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