New Insights into Type 2 Diabetes and Ketogenic Capacity

Researchers at Yonsei University in Seoul, South Korea, have made new discoveries about the relationship between ketogenic capacity and lipid profiles in individuals with prediabetes or newly diagnosed type 2 diabetes. The study found that patients with high levels of beta-hydroxybutyrate, a marker of ketogenic capacity, had more favorable lipid characteristics, including larger average LDL particle size, despite elevated LDL-C levels. This suggests that enhanced ketogenesis may not necessarily increase cardiovascular risk in these individuals.

Key Takeaways:

• Patients with prediabetes or newly diagnosed type 2 diabetes who exhibit enhanced ketogenesis have more favorable lipid characteristics, including larger average LDL particle size, despite elevated LDL-C levels.
• The enhanced ketogenesis group demonstrated better lipid profiles, including lower triglyceride levels and higher HDL-C levels, compared to the non-enhanced group.
• The study found no significant difference in cardiovascular risk factors between the two groups, suggesting that enhanced ketogenesis may not necessarily increase cardiovascular risk in patients with T2D or prediabetes.
• The research was conducted on 27 patients with high LDL-C levels and low TG levels, who were divided into two groups based on serum beta-hydroxybutyrate levels.
• The study's findings suggest that ketogenic capacity may play a role in modulating lipid profiles and cardiovascular risk in patients with T2D or prediabetes.
• The research was supported by the Korean Diabetes Association and published in the International Journal of Molecular Sciences.

Statistics:

• 27 individuals with high LDL-C levels (≥ 100 mg/dL) and low TG levels (
• Yonsei University. (n.d.). College of Medicine, Dept. of Internal Medicine, Division of Endocrinology. Retrieved from