Olmesartan Medoxomil Effective in Controlling Blood Pressure in Diabetic Patients

Diabetic patients with hypertension can effectively control their blood pressure using olmesartan medoxomil in combination with hydrochlorothiazide, according to a study published in Expert Opinion on Pharmacotherapy. The combination of this antihypertensive drug with a low-dose diuretic potentiates the blood pressure-lowering effect of either agent alone, achieving the recommended blood pressure goals in the majority of patients treated. This treatment approach is recommended by the American Diabetes Association as the primary option for patients with diabetic nephropathy.

Key Takeaways:

• Olmesartan medoxomil, in combination with hydrochlorothiazide, is effective in controlling blood pressure in diabetic patients with hypertension.
• The combination of olmesartan medoxomil with a low-dose diuretic potentiates the blood pressure-lowering effect of either agent alone.
• The American Diabetes Association recommends angiotensin receptor blockers (ARBs) as the primary treatment option for diabetic patients with hypertension.
• ARBs function by blocking the binding of angiotensin-II to its receptor, thereby inhibiting the action of A-II.
• Unlike ACE inhibitors, which block the production of A-II through the ACE pathway, ARBs effectively inhibit A-II regardless of the production pathway.
• Olmesartan medoxomil is a long-acting, safe, and well-tolerated antihypertensive drug.
• The study's authors, Steven G. Chrysant and George S. Chrysant, reported that the combination of olmesartan medoxomil with hydrochlorothiazide is highly effective in achieving the recommended blood pressure goals in the majority of patients treated.

Statistics:

• 5(3): 657-667 is the volume and page range of the study report in Expert Opinion on Pharmacotherapy.
• 657 is the starting page number of the study report in Expert Opinion on Pharmacotherapy.
• 2004 is the year in which the study was published.
• The University of Oklahoma is the institution associated with the study authors.

Sources:

• Chrysant, Steven G., and George S. Chrysant. "Antihypertensive efficacy of olmesartan medoxomil alone and in combination with hydrochlorothiazide." Expert Opin Pharmacother 5, no. 3 (2004): 657-667.
• American Diabetes Association. "Standards of Medical Care in Diabetes."
• Ashley Publications Ltd.