Personalized Medicine Breakthroughs in Gastric Cancer Research

Researchers from the Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chengdu Medical College, have made significant strides in understanding the role of preoperative neutrophil-to-albumin ratio as a prognostic indicator in advanced gastric cancer undergoing radical gastrectomy. Their study, published in Therapeutics and Clinical Risk Management, aimed to evaluate the prognostic significance of the preoperative neutrophil-to-albumin ratio in patients with advanced gastric cancer undergoing radical gastrectomy.

Key Takeaways:

• The preoperative neutrophil-to-albumin ratio is an independent and reliable prognostic biomarker for overall and recurrence-free survival in patients with advanced gastric cancer undergoing radical gastrectomy.
• High neutrophil-to-albumin ratio values were significantly associated with advanced tumor stage, incomplete resection status, administration of chemotherapy and radiotherapy, and poor histological differentiation.
• The optimal NAR cut-off value was identified as 2.8, with patients in the high-NAR group exhibiting significantly worse overall survival and recurrence-free survival compared to the low-NAR group.
• The research suggests that the preoperative neutrophil-to-albumin ratio can effectively facilitate risk stratification, personalized clinical decision-making, and targeted interventions to improve patient outcomes.

Statistics:

• 526 patients diagnosed with locally advanced gastric adenocarcinoma were involved in the retrospective analysis.
• Neutrophil count and serum albumin levels were obtained within 24 hours of admission.
• The optimal NAR cut-off value was 2.8.
• Patients with high NAR exhibited significantly worse overall survival and recurrence-free survival compared to the low-NAR group.
• High NAR was significantly associated with advanced tumor stage (P < 0.001), incomplete resection status (P < 0.001), administration of chemotherapy (P < 0.001), and radiotherapy (P < 0.001), and poor histological differentiation (P < 0.001).

Sources:

• Ye H, Kang R, Chen M, Zhang S, Yang JF. Preoperative Neutrophil-to-Albumin Ratio as a Prognostic Indicator in Advanced Gastric Cancer Undergoing Radical Gastrectomy. Therapeutics and Clinical Risk Management, 2025, Volume 21, Issue 1:1107-1119.
• NewsRx LLC. Recent Findings in Personalized Medicine Described by Researchers from Department of Gastrointestinal Surgery. Cancer Weekly. August 5, 2025; p 668.