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Pregnant women

Pregnancy-Associated Fulminant Type 1 Diabetes Mellitus: Two Case Reports and Literature Review

Strategic Insights

— 2 min read

Fresh data on Nutritional and Metabolic Diseases and Conditions - Type 1 Diabetes are presented in a new report. A recent study published in Experimental and Therapeutic Medicine, reported two cases of pregnancy-associated fulminant type 1 diabetes mellitus (PFT1DM) with favorable fetal outcomes. The study emphasizes the importance of early diagnosis and appropriate treatments to improve pregnancy outcomes, especially in cases where diabetic ketoacidosis symptoms are present. The researchers highlight the need for clinicians to be vigilant of PFT1DM in pregnant women and to implement systematic monitoring of blood glucose, HbA1c, and C-peptide before initiating treatments.

Key Takeaways:

  • Two cases of pregnancy-associated fulminant type 1 diabetes mellitus (PFT1DM) were reported in the study, with both patients experiencing favorable fetal outcomes.
  • The patients were a 35-year-old woman at 17 weeks of gestation and a 28-year-old woman at 26 weeks of gestation, both diagnosed with PFT1DM.
  • Elevated fasting blood glucose, near-normal glycosylated hemoglobin (HbA1c) levels, and low serum fasting C-peptide indicated severe pancreatic beta-cell dysfunction in both patients.
  • Serum glutamic acid decarboxylase antibody (GAD-Ab) testing was negative, confirming the diagnosis of PFT1DM.
  • Both patients were treated with intravenous insulin and rehydration therapy to correct diabetic ketoacidosis, followed by daily subcutaneous insulin injections.
  • A healthy male baby was delivered in both cases, with birth weights of 3,350 and 3,410 grams, respectively.
  • The study emphasizes the importance of early diagnosis and systematic monitoring of blood glucose, HbA1c, and C-peptide in pregnant women presenting with diabetic ketoacidosis symptoms.
  • Testing for GAD-Ab helps confirm the diagnosis of PFT1DM, and enhancing awareness and education about PFT1DM is essential for preventing adverse prognosis in mothers and infants.
  • The study has been peer-reviewed and published in Experimental and Therapeutic Medicine.

Statistics:

  • Birth weight of the first baby: 3,350 grams
  • Birth weight of the second baby: 3,410 grams
  • Age of the first patient at diagnosis: 35 years old
  • Age of the second patient at diagnosis: 28 years old
  • Number of cases reported in the study: 2
  • Percentage of pregnant women experiencing PFT1DM: Not specified
  • Duration of treatment before delivery: Not specified

Sources:

  • Fan, K., Lv, J., Cheng, D., Zhang, L., Wang, X., & Li, N. (2025). Pregnancy-associated Fulminant Type 1 Diabetes Mellitus: Two Case Reports and Literature Review. Experimental and Therapeutic Medicine, 30(3).
  • Spandidos Publ Ltd. (Pob 18179, Athens, 116 10, Greece). Contact: Jinan Maternity and Child Care Hospital, Dept. of Obstetrics, Jianguo Small Jingsan Rd, Jinan 250001, Shandong, People's Republic of China.

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