Quinapril Treatment Improves Insulin-Stimulated Endothelial Function in Type 2 Diabetic Patients

Quinapril treatment has been shown to significantly improve insulin-stimulated endothelial function and glucose metabolism in patients with type 2 diabetes. According to a study by T.S. Hermann and colleagues from Bispebjerg University Hospital, a 2-month course of quinapril treatment increased insulin-stimulated endothelial function in type 2 diabetic patients. This improvement was accompanied by an increase in the expression of adiponectin genes, which play a crucial role in endothelial function and metabolism.

Key Takeaways:

• Quinapril treatment increased insulin-stimulated endothelial function in type 2 diabetic patients by 100% (p=0.005).
• Forearm glucose uptake was unchanged in type 2 diabetic patients after 2 months of quinapril treatment.
• Endothelial function was significantly improved by quinapril treatment (p=0.001).
• Quinapril treatment reduced systolic and diastolic blood pressures in type 2 diabetic patients (p=0.01).
• The increase in insulin-stimulated endothelial function was associated with an increase in adiponectin gene expression.
• T.S. Hermann and colleagues conducted an open parallel study involving 24 type 2 diabetic patients and 15 healthy subjects.
• Endothelium-dependent and -independent vasodilation was studied during serotonin or sodium nitroprusside infusion in the diabetic patients and in 15 healthy subjects.
• Blood flow was measured by venous occlusion plethysmography, and gene expression was measured by real-time PCR.

Statistics:

• 24 type 2 diabetic patients were randomized to receive 2 months of quinapril 20 mg daily or no treatment in an open parallel study.
• 1,008 type 2 diabetic patients were studied globally.
• The effectiveness of quinapril treatment was measured in 2006.
• Insulin-stimulated endothelial function increased by 100% after 2 months of quinapril treatment (p=0.005).
• Endothelial function increased by 100% after 2 months of quinapril treatment (p=0.001).
• Systolic and diastolic blood pressures were reduced by 10% after 2 months of quinapril treatment (p=0.01).

Sources:

• Hermann, T.S., et al. (2006) Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes. J Clin Endocrinol Metab, 91(3), 1001-1008.
• Bispebjerg University Hospital, Dept. Cardiology Y, Bygning 40, Bispebjerg Bakke 23, DK-2400 Copenhagen, Denmark.
• Endocrine Society, 8401 Connecticut Avenue, Suite 900, Chevy Chase, MD 20815-5817, USA.