Research Reveals Trends and Hotspots in Gastric Cancer Biomarkers

A new study from West Kazakhstan Marat Ospanov Medical University aims to quantify the accumulated knowledge about the prognostic value of stomach cancer biomarkers in the context of the morphological Lauren's classification. The analysis of 162 publications from 1995 to 2024 revealed significant growth in research on gastric cancer biomarkers, with China being the leading country in this field. The study highlights the importance of understanding the role of biomarkers in predicting gastric cancer prognosis based on Lauren's classification.

Key Takeaways:

• The study aimed to quantify the accumulated knowledge about the prognostic value of stomach cancer biomarkers in the context of the morphological Lauren's classification.
• A literature search was conducted in the Scopus database in December 2024, selecting 162 publications for the period 1995-2024.
• The analysis was performed using the statistical software RStudio, widely used in scientific research, and the specialized Biblioshiny package for data analysis and visualization.
• The average annual growth rate was 3.86%, and the average number of citations per article was 30.4, highlighting the high importance of the topic of the study.
• The largest number of publications originated from China, with 292 articles, and the most prolific author is Zhang J., who conducted 13 studies in this field.
• The journal Pathology - Research and Practice holds the leading position with 8 publications, and the most frequently occurring keyword is 'gastric cancer' (94 mentions).
• Thematic trends include research on HER2 and microsatellite instability, and the bibliometric analysis revealed the active development of research on the role of biomarkers in predicting gastric cancer prognosis based on Lauren's classification.

Statistics:

• 162 publications were selected for analysis from 1995 to 2024.
• 3.86% was the average annual growth rate.
• 30.4 was the average number of citations per article.
• 292 articles originated from China.
• Zhang J. conducted 13 studies in this field.
• 8 publications were from the journal Pathology - Research and Practice.
• 'Gastric cancer' was mentioned 94 times as the most frequently occurring keyword.

Sources:

• Trends and hot spots in research on the prognostic value of gastric cancer biomarkers in the context of the Lauren classification: a bibliometric analysis. Frontiers in Medicine, 2025;12:1612256.
• NewsRx. West Kazakhstan Marat Ospanov Medical University Reports Findings in Cancer Biomarkers (Trends and hot spots in research on the prognostic value of gastric cancer biomarkers in the context of the Lauren classification: a bibliometric analysis). Health & Medicine Week. August 22, 2025; p 8496.