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Cancer research

Research Uncovers Promising Sensor for Detecting Cancer Biomarkers

Strategic Insights

— 1 min read

A recent study has shed new light on the use of Cobalt-doped Graphitic Carbon Nitride (g-C3N4) as a potential sensor for detecting cancer biomarkers. The research, conducted by a team led by Mausumi Chattopadhyaya at the National Institute of Technology Calicut, India, employed Density Functional Theory (DFT) calculations to investigate the sensitivity of various biomarkers, including acetone, ethanol, and aniline, on both pristine and Cobalt-doped g-C3N4 systems.

Key Takeaways:

  • The study found that Cobalt-doped g-C3N4 exhibits superior conductivity and physisorption behavior, making it a promising sensor for detecting aniline, a biomarker associated with cancer.
  • The sensor's recovery time is significantly faster for aniline, with a recovery time of 0.09 seconds at 398 K.
  • The study's results indicate that Cobalt-doped g-C3N4 can selectively detect acetone, ethanol, and aniline biomarkers via chemisorption, physisorption, and intermediate adsorption, respectively.
  • The researchers note that their findings predict Cobalt-doped g-C3N4 to be a superior sensor for detecting aniline due to its physisorption behavior, lower recovery time, higher conductivity, and significant change in work function.
  • The study has been peer-reviewed and concluded that Cobalt-doped g-C3N4 is a state-of-the-art sensor for detecting aniline in exhaled breath, a discovery previously unknown.
  • The research was supported by the Science Engineering Research Board (SERB), India, and the University Grants Commission, India.

Statistics:

  • The adsorption energy calculations reveal that acetone undergoes chemisorption on pristine g-C3N4, resulting in long recovery times (63.11µs).
  • The conductivity of Cobalt-g-C3N4 (5.11 x 10^(-9) S/m) is higher than that of pristine g-C3N4 (5.714 x 10^(-12) S/m).
  • The recovery time for aniline is 0.09 seconds at 398 K, while ethanol exhibits a recovery time of 3.64 seconds at the same temperature.
  • The sensor's work function changes significantly, suggesting its potential for detecting aniline biomarkers.

Sources:

  • Chattopadhyaya, M. et al. (2025). Density Functional Theoretical Method for Modelling Cobalt-doped G-c 3 n 4 Sensor for Detecting Acetone, Ethanol, and Aniline - Cancer Biomarkers. ChemistrySelect, 2025;10(15).
  • NewsRx. Recent Studies from National Institute of Technology Calicut Add New Data to Cancer Biomarkers (Density Functional Theoretical Method for Modelling Cobalt-doped G-c 3 n 4 Sensor for Detecting Acetone, Ethanol, and Aniline - ...). Health & Medicine Week. May 23, 2025; p 3636.

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