Sign in Subscribe
Diseases

Researchers Develop New Antibodies to Improve Foot and Mouth Disease Virus Vaccine Quality Control

Strategic Insights

— 1 min read

Investigators at Wageningen Bioveterinary Research have made a significant breakthrough in developing new antibodies that specifically recognize intact capsids of multiple foot-and-mouth disease serotype O strains. This achievement has substantial implications for improving vaccine quality control against the virus. The research was supported by the Ministry of Agriculture, Nature And Food Quality, The Netherlands. The study aimed to isolate 146S-specific single-domain antibodies (VHHs) that recognize all serotype O strains, which would enable improved vaccine quality control.

Key Takeaways:

  • Researchers at Wageningen Bioveterinary Research have isolated four VHHs (M907F, M910F, M912F, and M916F) that specifically bind 146S particles of probably all serotype O strains.
  • These VHHs enable further improved FMDV vaccine quality control by recognizing the same antigenic site as M170F, which is conserved in serotypes A and O.
  • The study used biopanning and phage-display libraries from llamas immunized with other serotype O strains to select for VHHs with high 146S specificity for all five serotype O strains analyzed.
  • These VHHs have a lower limit of detection, varying from 0.7 to 5.9 ng/mL 146S particles for three serotype O strains.
  • The research was funded by the Ministry of Agriculture, Nature And Food Quality, The Netherlands.
  • The study's findings were published in the journal Vaccines, 2025,13(5):500.

Statistics:

  • Four VHHs (M907F, M910F, M912F, and M916F) were isolated that specifically bind 146S particles of probably all serotype O strains.
  • The VHHs recognized the same antigenic site as M170F, which is conserved in serotypes A and O.
  • The study used biopanning and phage-display libraries from llamas immunized with other serotype O strains to select for VHHs with high 146S specificity for all five serotype O strains analyzed.
  • The VHHs had a lower limit of detection, varying from 0.7 to 5.9 ng/mL 146S particles for three serotype O strains.

Sources:

  • NewsRx (NewsRx. Research Study Findings from Wageningen Bioveterinary Research Update Understanding of Foot and Mouth Disease Virus (Single-Domain Antibodies That Specifically Recognize Intact Capsids of Multiple Foot-and-Mouth Disease Serotype O Strains). Life Science Weekly. June 10, 2025; p 4530.)
  • Vaccines (Single-Domain Antibodies That Specifically Recognize Intact Capsids of Multiple Foot-and-Mouth Disease Serotype O Strains. Vaccines, 2025,13(5):500.)

Read more