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HIV

Researchers Develop New Mathematical Model to Study HIV and SARS-CoV-2 Coinfection Dynamics

Strategic Insights

— 1 min read

Researchers at the University of Porto have developed a novel mathematical model to capture the coinfection dynamics of HIV and SARS-CoV-2 under the influence of highly active antiretroviral therapy (HAART). The model takes into account the effect of HAART on both infections and derives the basic reproduction numbers for each virus. Numerical simulations show that HAART not only controls HIV but also reduces SARS-CoV-2 proliferation in coinfected hosts, providing new theoretical insights into the control of viral coinfections.

Key Takeaways:

  • The researchers developed a new mathematical model to study the coinfection dynamics of HIV and SARS-CoV-2 under HAART, which includes the effect of HAART on both infections and derives the basic reproduction numbers for each virus.
  • Numerical simulations show that HAART reduces SARS-CoV-2 proliferation in coinfected hosts, providing new insights into the control of viral coinfections.
  • The model reveals a potentially beneficial indirect effect of antiretroviral therapy on SARS-CoV-2 dynamics.
  • The researchers found that transcritical bifurcations occur when the basic reproduction numbers cross the threshold value of 1.
  • The conditions for stability of the disease-free equilibria are established.
  • The model is a significant contribution to the understanding of the interaction between HIV and SARS-CoV-2 in coinfected individuals.

Statistics:

  • The study was supported by FCT-FCCN (b-on).
  • The research has been peer-reviewed.
  • The study was published in Applications of Mathematics in 2025.
  • The University of Porto is a major research institution in Portugal, with a strong focus on mathematics and biomedical research.

Sources:

  • Qualitative Analysis of Haart Effects On Hiv and Sars-cov-2 Coinfection Model. Applications of Mathematics, 2025.
  • NewsRx. Studies from University of Porto Yield New Information about HIV/AIDS (Qualitative Analysis of Haart Effects On Hiv and Sars-cov-2 Coinfection Model). AIDS Weekly. October 20, 2025; p 417.

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