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Coronary heart disease

Sex- and Age-Related Differences in Inflammatory Markers and Their Association with Coronary Artery Disease

Strategic Insights

— 1 min read

Current study results on heart disorders and diseases have been published in the journal Cardiology, focusing on the differences in circulating cytokines between sexes and age and their association with the pathogenesis of coronary artery disease (CAD) in hospitalized patients. The retrospective study, conducted between October 2022 and November 2024, included 2,208 participants who underwent coronary angiography and aimed to identify populations suitable for anti-inflammatory treatment.

Key Takeaways:

  • The study explored sex- and age-related differences in circulating inflammatory cytokine levels and CAD occurrence in hospitalized patients who underwent coronary angiography between October 2022 and November 2024.
  • A total of 2,208 participants were included in the study, with 931 women and 1,277 men, and 1,270 participants aged 65 years or older.
  • Univariate logistic regression analysis was used to assess the association of cytokines with the incidence of CAD, which was significantly different between age and sex groups.
  • The selected participants were grouped by age and sex to compare differences in circulating inflammatory cytokine levels and CAD occurrence.
  • A total of 2,208 participants (931 women and 1,277 men) were included in the study, with 1,270 participants aged 65 years or older.
  • The study concluded that due to the retrospective design, there may be unmeasured confounding factors, and future prospective studies are still needed to further verify these associations.
  • The study was peer-reviewed and published in the journal Cardiology.

Statistics:

  • 2,208 participants were included in the study.
  • 931 women and 1,277 men participated in the study.
  • 1,270 participants aged 65 years or older.
  • Odds ratios (ORs) with 95% confidence intervals (CIS) were used to assess the association of cytokines with the incidence of CAD.
  • Variables included in the multivariate adjustment model were selected based on their significance as traditional risk factors in the univariate analysis.

Sources:

  • Sex- and Age-Related Differences in Inflammatory Markers and Their Association with Coronary Artery Disease. Cardiology, 2025:1-13.
  • Rui Chen, Dept. of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, People's Republic of China.
  • Ye Zhou, Junying Duan, Minghai Wu, Ye Su, Duzhe Jiang, and Zhiying Dai, Department of Cardiology, Affiliated Hospital of Jiangsu University.
  • Karger, Allschwilerstrasse 10, Ch-4009 Basel, Switzerland (Karger - www.karger.com/; Cardiology - content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr=223832).

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