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Mediation

Socioeconomic Status Linked to Reduced Risk of Irritable Bowel Syndrome

Strategic Insights

— 2 min read

A recent study from Capital Medical University has found a significant association between socioeconomic status (SES) and the risk of incident irritable bowel syndrome (IBS). The research, published in Clinical Gastroenterology and Hepatology, analyzed a cohort of 353,790 participants and found that higher SES was associated with a lower risk of IBS, with a hazard ratio of 0.61 (95% CI, 0.57-0.66) between high and low SES patterns. The study also found that a healthy lifestyle score, including never smoking, moderate alcohol consumption, healthy diet, regular physical activity, normal body mass index, and healthy sleep duration, mediated 10.2% of the effect between high SES and reduced IBS risk.

Key Takeaways:

  • The study included 353,790 participants, with 7240 (2.1%) incident IBS cases identified during a median follow-up of 14.5 years.
  • 94,660 (26.7%), 186,317 (52.7%), and 72,813 (20.6%) participants were classified into low, medium, and high SES patterns, respectively.
  • A high SES pattern was associated with lower IBS risk compared to a low SES pattern, with a hazard ratio of 0.61 (95% CI, 0.57-0.66).
  • Healthy lifestyle factors mediated 10.2% of the effect between high SES and reduced IBS risk.
  • Individual SES items, such as higher household income, education, and employed status, were linked to 8-32% lower IBS risk.
  • Participants with high SES pattern and healthy lifestyle score of 5 or 6 had a 55% (hazard ratio, 0.45; 95% CI, 0.39-0.51) reduced IBS risk compared to those with a low SES pattern and healthy lifestyle score of 0-2.

Statistics:

  • 353,790 participants were included in the study.
  • 7240 (2.1%) incident IBS cases were identified during the study period.
  • 94,660 (26.7%), 186,317 (52.7%), and 72,813 (20.6%) participants were classified into low, medium, and high SES patterns, respectively.
  • The hazard ratio for high vs. low SES pattern was 0.61 (95% CI, 0.57-0.66).
  • 10.2% of the effect between high SES and reduced IBS risk was mediated by healthy lifestyle factors.
  • The hazard ratio for high SES pattern and healthy lifestyle score of 5 or 6 vs. low SES pattern and healthy lifestyle score of 0-2 was 0.45 (95% CI, 0.39-0.51).

Sources:

  • NewsRx. Data from Capital Medical University Provide New Insights into Irritable Bowel Syndrome (Socioeconomic Disparity and Risk of Irritable Bowel Syndrome: A Cohort Study With Mediation Analysis). Clinical Trials Week. October 20, 2025; p 72.
  • Socioeconomic Disparity and Risk of Irritable Bowel Syndrome: A Cohort Study With Mediation Analysis. Clinical Gastroenterology and Hepatology, 2025.

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