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Stereotactic Radiosurgery for Olfactory Groove Meningiomas: 35-Year Single-Institution Experience

Strategic Insights

— 1 min read

Research from the University of Pittsburgh Medical Center has shed light on the outcomes of stereotactic radiosurgery (SRS) for patients with olfactory groove meningiomas (OGMs). A new study published in Neurosurgery compares the effectiveness of primary SRS versus salvage SRS in managing OGMs. The study, conducted over 35 years, evaluated the radiographic imaging of 2030 patients who underwent SRS between 1987 and 2022.

Key Takeaways:

  • The study found that primary SRS provided superior local tumor control (LTC) and preservation or improvement of olfactory function in most patients.
  • Of the 78 patients with OGM, 48 underwent primary SRS and 31 had previous resections.
  • The median tumor volume was 4.30 cc (range, 0.19-26.90 cc), and the median margin dose prescribed at SRS was 13 Gy (range, 9-18 Gy).
  • The overall survival for all OGM patients was 17 years (range, 0.8-24.3 years), with no patient deaths related to intracranial tumor progression.
  • Delayed tumor progression was observed in 7 patients (22.5%) who underwent salvage SRS, at a median time of 6.4 years (range, 0.4-15.2 years) after SRS.
  • Previous resection was associated with anosmia (P<0.0001).

Statistics:

  • 2030 patients with meningiomas underwent SRS between 1987 and 2022.
  • 78 patients with OGM were identified, with 48 undergoing primary SRS and 31 having previous resections.
  • Median tumor volume: 4.30 cc (range, 0.19-26.90 cc).
  • Median margin dose prescribed at SRS: 13 Gy (range, 9-18 Gy).
  • Overall survival for all OGM patients: 17 years (range, 0.8-24.3 years).
  • Delayed tumor progression in salvage SRS patients: 22.5% (7/31).

Sources:

  • Primary Versus Salvage Stereotactic Radiosurgery for Patients With Olfactory Groove Meningiomas: A 35-Year Single-Institution Experience. Neurosurgery, 2025.
  • Lippincott Williams & Wilkins, Two Commerce Sq, 2001 Market St, Philadelphia, PA 19103, USA. (Lippincott Williams and Wilkins - www.lww.com; Neurosurgery - journals.lww.com/neurosurgery/pages/default.aspx)
  • University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States.

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