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Agricultural industry

Sulfated Fucan Polysaccharide Show Promise as Anti-Inflammatory Agents

Strategic Insights

— 1 min read

Researchers from Chiang Mai University have identified a potential anti-inflammatory agent in sulfated fucan polysaccharides from Holothuria scabra. The study, published in the Journal of Agriculture and Food Research, demonstrated that these polysaccharides, particularly a derivative known as HSP2, exhibited significant anti-inflammatory properties by reducing NO generation and downregulating inflammatory mediators. These findings suggest that H. scabra polysaccharides may hold promise for managing immunological and inflammatory diseases.

Key Takeaways:

  • The study used RAW264.7 cells to investigate the effects of crude polysaccharides and their fractions on LPS-induced inflammatory responses.
  • The crude polysaccharides and fractions primarily comprised carbohydrates, proteins, and sulfates, ranging from 51.5 to 62.2%, 11.3-22.2%, and 18.9-30.7%, respectively.
  • The study utilized DESAE cellulose ion exchange chromatography to purify the polysaccharides, yielding two fractions: F1 and F2.
  • The F2 polysaccharide demonstrated significant anti-inflammatory properties by reducing NO generation.
  • The DESAE-derived F2 polysaccharide, HSP2, exhibited a significantly greater reduction in NO levels in LPS-induced RAW264.7 cells.
  • The findings suggest that H. scabra polysaccharides, particularly HSP2, hold promise as anti-inflammatory agents for the management of immunological and inflammatory diseases.
  • The study suggested that the polysaccharides may modulate NF-kB and MAPK signaling pathways to exert their anti-inflammatory effects.

Statistics:

  • The molecular weights of the crude polysaccharides ranged from 315.3 to 429.6 kDa.
  • The carbohydrate content of the crude polysaccharides ranged from 51.5 to 62.2%.
  • The protein content of the crude polysaccharides ranged from 11.3 to 22.2%.
  • The sulfate content of the crude polysaccharides ranged from 18.9 to 30.7%.
  • The study observed a significant reduction in NO generation in LPS-induced RAW264.7 cells treated with F2 polysaccharide.

Sources:

  • Journal of Agriculture and Food Research, 2025, 22():102122.
  • Publisher: Elsevier.
  • DOI: https://doi-org.sdpl.idm.oclc.org/10.1016/j.jafr.2025.102122.

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