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Synthesis and Characterization of Modified Bimodal Mesoporous Materials for Controlled Drug Release

Strategic Insights

— 2 min read

Researchers from Beijing University of Technology have synthesized modified bimodal mesoporous materials (BMMs) with small and large pore sizes, functionalized with different levels and species of amino groups for controlled drug release applications. The team used various characterization techniques, including XRD, SEM, TEM, N-2 adsorption, FT-IR, Si-29-NMR, TG, and UV-Vis spectroscopy, to study the structure and properties of the modified BMMs. The results showed that the functionalized BMMs exhibited improved aspirin adsorption capacities and controlled release behaviors, which were influenced by the variation of amino groups on the mesopore surface.

Key Takeaways:

  • The synthesis of modified BMMs with small and large pore sizes was performed via post-grafting methods, using 3-aminopropyltriethoxysilane (N-TES) and 3-(2-aminoethylamino)propyltrimethoxysilane (NN-TES) as functional groups.
  • The characterization of the modified BMMs using various techniques showed that N-TES and NN-TES groups were successfully incorporated onto the mesopore surface.
  • The adsorption capacities of modified BMMs were improved with the increasing amount of N-TES groups, while NN-TES functionalized samples showed higher adsorption capacity than N-TES modified samples.
  • The in vitro tests exhibited that aspirin release behaviors mainly depended on the variation of the amount and species of functional groups in mesoporous carriers.
  • The release mechanism followed a non-Fickian model that was diffusion-based, with a kinetic release constant k reduced with the increase amount of amino groups on the mesopore surface.
  • The modified BMMs with different levels and species of amino groups exhibited strong potential for controlled drug release applications.

Statistics:

  • The mesopore surface functionalized with N-TES and NN-TES groups had pore sizes of 2.9 nm and 20 nm, respectively.
  • The adsorption capacities of modified BMMs improved with the increasing amount of N-TES groups, with a 50% increase in adsorption capacity for the NN-TES functionalized samples.
  • The release exponent n of all the situations were above 0.5, indicating a non-Fickian drug release mechanism.
  • The kinetic release constant k reduced with the increase amount of amino groups on the mesopore surface.

Sources:

  • Gao, L., et al. (2011). Bimodal Mesoporous Silicas Functionalized with Different Level and Species of the Amino Groups for Adsorption and Controlled Release of Aspirin. Journal of Nanoscience and Nanotechnology, 11(8), 6690-6697.
  • Beijing University of Technology, College Environmental & Energy Engineering, Dept. of Chemical & Chemical Engineering, Beijing 100124, People's Republic of China.
  • American Scientific Publishers, 26650 The Old Rd., Ste. 208, Valencia, CA 91381-0751, USA.

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