Diseases

Diseases

Macrophage Plasticity Plays Crucial Role in Autoimmune and Inflammatory Rheumatic Diseases

Researchers have discovered that macrophages play a key role in regulating inflammatory and fibrotic processes in several autoimmune and inflammatory rheumatic diseases. Macrophages are highly plastic cells that can shift between pro-inflammatory and anti-inflammatory phenotypes in response to environmental factors and cytokine signatures. This plasticity is enhanced in synovial tissue