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Coronary heart disease

Triglyceride-Glucose Index Emerges as Novel Prognostic Biomarker for Coronary Artery Disease

Strategic Insights

— 1 min read

A prospective cohort study conducted at Beijing Hospital found that the triglyceride-glucose (TyG) index, a biomarker combining fasting glucose and triglyceride levels, correlates with increased all-cause death, cardiovascular disease (CVD) death, and major adverse cardiovascular events (MACE) risks in patients with coronary artery disease (CAD). The study included 23,591 patients with CAD and demonstrated the long-term prognostic value of the TyG index in both acute coronary syndrome (ACS) and chronic coronary syndrome (CCS).

Key Takeaways:

  • The TyG index is a promising biomarker for coronary artery disease (CAD) and correlates with increased risks of all-cause death, CVD death, and major adverse cardiovascular events (MACE).
  • The study involved 23,591 patients with CAD and demonstrated the long-term prognostic value of the TyG index in both acute coronary syndrome (ACS) and chronic coronary syndrome (CCS).
  • Continuous TyG index was an independent risk factor for all-cause death (HR = 1.22; 95% CI 1.02-1.45) and CVD death (HR = 1.61; 95% CI 1.17-2.22).
  • Patients with chronic coronary syndrome (CCS) in the highest TyG tertile group had a 2.15-fold higher risk of CVD death (95% CI 1.10-4.23).
  • The study suggests that the TyG index may be a useful prognostic tool for CAD patients, particularly in CCS.

Statistics:

  • 23,591 patients with CAD were included in the study.
  • 11,325 CAD patients were included in the final analysis.
  • The median follow-up duration was 28 months.
  • All-cause death risk increased by 1.22-fold (95% CI 1.02-1.45) with higher TyG index.
  • CVD death risk increased by 1.61-fold (95% CI 1.17-2.22) with higher TyG index.
  • MACE risk increased by 1.17-fold (95% CI 1.00-1.37) with higher TyG index.
  • Patients with CCS in the highest TyG tertile group had a 2.15-fold higher risk of CVD death (95% CI 1.10-4.23).

Sources:

  • Triglyceride-glucose Index As a Novel Prognostic Biomarker for Coronary Artery Disease: Evidence From a Large-scale Prospective Cohort Study. Frontiers in Endocrinology, 2025;16.
  • Capital Medical University, Beijing Anzhen Hospital, Dept. of Cardiology, Beijing, People's Republic of China.
  • Frontiers Media Sa, Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland.

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