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Cardiac patients

Trimetazidine Associated with Lower Stroke Risk in Patients with Atrial Fibrillation

Strategic Insights

— 1 min read

Researchers from the Department of Medicine at the University of Hong Kong have found that trimetazidine, a medication used to treat chest pain, is associated with a lower risk of stroke in patients with ischemic heart disease and atrial fibrillation. The study, published in the Journal of the American Heart Association, analyzed data from over 12,500 patients and found that those taking trimetazidine had a 45% lower risk of new-onset ischemic stroke. The findings suggest that trimetazidine may be a useful treatment option for patients with both conditions.

Key Takeaways:

  • The study analyzed data from 12,527 patients with ischemic heart disease and preexisting atrial fibrillation, with a mean age of 77.5 years and 44.6% men.
  • Over a follow-up period of 1133 days, 2,160 patients (17.2%) developed new-onset ischemic stroke.
  • Trimetazidine use was independently associated with a lower risk of new-onset ischemic stroke (hazard ratio [HR], 0.55 [95% CI, 0.44-0.68]; P <
  • The study found that trimetazidine users had a lower risk of incident and recurrent stroke in patients with both ischemic heart disease and atrial fibrillation.
  • The researchers concluded that treatment with trimetazidine is associated with a lower risk of incident and recurrent stroke in patients with both ischemic heart disease and atrial fibrillation.

Statistics:

  • 12,527 patients with ischemic heart disease and preexisting atrial fibrillation were included in the study.
  • 2,160 patients (17.2%) developed new-onset ischemic stroke over a follow-up period of 1133 days.
  • Trimetazidine users had a 45% lower risk of new-onset ischemic stroke (hazard ratio [HR], 0.55 [95% CI, 0.44-0.68]; P <
  • 960 patients were trimetazidine users, compared to 11,567 non-users.

Sources:

  • Trimetazidine Is Associated With Ameliorated Stroke Risk in Patients With Both Ischemic Heart Disease and Atrial Fibrillation. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2025,14(19).

(Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease - http://jaha.ahajournals.org).

The publisher for Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease is Wiley.

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