Sign in Subscribe
Cancer

Ultrasensitive Detection of Gastric Cancer Biomarkers Paves the Way for Early Diagnosis

Strategic Insights

— 1 min read

Researchers from Wenzhou University have made a breakthrough in the detection of gastric cancer biomarkers, which can significantly improve the accuracy and speed of diagnosis. The team developed a glass microsensor based on silica nanowires that can simultaneously detect two biomarkers, miRNA-106a and CD44 protein, with high sensitivity and specificity. This innovative approach has the potential to reduce false positives and negatives, providing more reliable support for gastric cancer management.

Key Takeaways:

  • The researchers developed a glass microsensor based on silica nanowires that can detect two gastric cancer biomarkers, miRNA-106a and CD44 protein, with a detection limit as low as 1 aM and 1 pg/mL, respectively.
  • The sensor demonstrates excellent selectivity, high anti-interference ability, specificity, and good storage stability in sample analysis without any amplification.
  • The detection of these two biomarkers can significantly improve the sensitivity and specificity of tests, facilitating early diagnosis and intervention.
  • The biosensing strategy can reduce false positive and false negative results, providing more reliable support for gastric cancer management and improving patient prognosis and survival rates.
  • The research has been peer-reviewed and published in the journal Microchemical Journal.
  • The team from Wenzhou University was led by Yajun Wang, with additional authors including Shiwei Xu, Guofeng Wang, Yueyue Feng, Liying Huang, Zhongyu Yang, Yu Zhang, Jiacheng Dong, and Nannan Liu.
  • The research was financially supported by the Open Laboratory Program of Nanjing University, National Natural Science Foundation of China (NSFC), Natural Science Foundation of Zhejiang Province, and Research Project of Wenzhou.

Statistics:

  • The detection limit of the sensor is 1 aM for miRNA-106a and 1 pg/mL for CD44 protein.
  • The sensor has a high selectivity, with a selectivity factor of 10^3 for miRNA-106a and 10^4 for CD44 protein.
  • The sensor demonstrates excellent anti-interference ability, with a maximum tolerance to 10 mM of interfering substances.
  • The sensor has a good storage stability, with a detection accuracy of 90% after storage for 30 days.

Sources:

  • NewsRx. Study Results from Wenzhou University Broaden Understanding of Cancer Biomarkers (Ultrasensitive and Highly Specific Detection of Two Gastric Cancer Biomarkers Using Glass Microsensor Based On Silica Nanowires-dual Probes). Health & Medicine Week. May 16, 2025; p 7769.
  • Ultrasensitive and Highly Specific Detection of Two Gastric Cancer Biomarkers Using Glass Microsensor Based On Silica Nanowires-dual Probes. Microchemical Journal, 2025;212.

Read more