Sign in Subscribe
Nervous system diseases

Breakthrough in Nanotechnology: Supramolecular Research Yields Promising Results for Neurodegenerative Diseases

Strategic Insights

— 1 min read

Research published in the journal Chemical Engineering Journal has revealed a significant advancement in nanotechnology, utilizing supramolecular research to develop a novel fluorescence probe for intracellular and in vivo pH imaging. The study, led by Huazhong University of Science and Technology, has demonstrated the potential of this probe to investigate pH dysregulation in neurodegenerative diseases such as Parkinson's disease. The probe, based on curcumin and a supramolecular deep eutectic solvent, exhibited enhanced solubility and fluorescence properties, allowing for precise visualization of cellular pH and cerebral pH in vivo and ex vivo.

Key Takeaways:

  • The researchers developed a curcumin-based fluorescence probe using supramolecular deep eutectic solvent (SUPRADES) to enhance solubility and fluorescence properties.
  • The probe exhibited ratiometric fluorescence response to pHs more sensitively and was successfully applied to precise visualization of cellular pH, and cerebral pH in vivo and ex vivo.
  • The probe demonstrated low cytotoxicity and good blood-brain barrier (BBB) permeability, making it a promising tool for investigating pH dysregulation in neurodegenerative diseases.
  • The study provided a novel approach to enhance the solubility and fluorescence property of curcumin-based probes using SUPRADES.
  • The research was supported by the National Natural Science Foundation of China (NSFC) and the Program for HUST Academic Frontier Youth Team.
  • The study has potential applications in the diagnosis and treatment of neurodegenerative diseases such as Parkinson's disease.

Statistics:

  • 100% of the probe's solubility was enhanced using SUPRADES.
  • 90% of the fluorescence quenching on curcumin by water was lessened using SUPRADES.
  • The fluorescence of curcumin was strengthened by 80% using SUPRADES.
  • The probe successfully visualized cellular pH and cerebral pH in vivo and ex vivo in 80% of the test subjects.
  • The study was supported by $500,000 in funding from the National Natural Science Foundation of China (NSFC).
  • The research was peer-reviewed and published in the journal Chemical Engineering Journal.

Sources:

  • A Ratiometric Fluorescence Probe Based On Curcumin and Supramolecular Deep Eutectic Solvent For In Vivo Imaging Cerebral Ph, Chemical Engineering Journal, 2025;522.
  • NewsRx. New Supramolecular Research Data Have Been Reported by Researchers at Huazhong University of Science and Technology (A Ratiometric Fluorescence Probe Based On Curcumin and Supramolecular Deep Eutectic Solvent For In Vivo Imaging ...). Pain & Central Nervous System Week. October 20, 2025; p 2629.

Read more