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Elsevier Science Inc.

Diabetes Mellitus Does Not Increase Short-Term Risks Following Carotid Artery Stenting

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— 2 min read

Diabetes mellitus is a significant risk factor for vascular events, yet its impact on carotid artery stenting outcomes remains unclear. A recent study published in the Annals of Vascular Surgery aimed to determine whether diabetes mellitus increases perioperative risks after carotid artery stenting. The study conducted a systematic review and meta-analysis of 12 cohort studies involving 22,226 patients, including 7,415 diabetic patients. The results showed that diabetes mellitus was not significantly associated with increased risk of perioperative stroke, transient ischemic attack, myocardial infarction, all-cause mortality, and stroke/death composite. However, diabetes significantly increased the long-term risk of target-vessel restenosis.

Key Takeaways:

  • The study included 12 cohort studies involving 22,226 patients, including 7,415 diabetic patients.
  • Diabetes mellitus was not significantly associated with increased risk of perioperative stroke, TIA, MI, all-cause mortality, and stroke/death composite.
  • However, diabetes mellitus significantly increased the long-term risk of target-vessel restenosis by 210% (RR 2.10; 95% CI 1.18-3.73).
  • Heterogeneity was low, ranging from 0% to 37%.
  • Sensitivity analyses confirmed the stability of the results.
  • Funnel plots were symmetric, and the Egger test was nonsignificant (P = 0.383).
  • The study concluded that diabetes mellitus does not elevate short-term risks of stroke, TIA, MI, or death following carotid artery stenting.
  • However, it is associated with a significantly higher long-term risk of restenosis.

Statistics:

  • 12 cohort studies were included in the systematic review and meta-analysis.
  • 22,226 patients were involved in the 12 cohort studies, including 7,415 diabetic patients.
  • Diabetes mellitus was not significantly associated with increased risk of perioperative stroke (RR 1.16; 95% CI 0.79-1.69).
  • Diabetes mellitus was not significantly associated with increased risk of TIA (RR 1.42; 95% CI 0.98-2.06).
  • Diabetes mellitus was not significantly associated with increased risk of MI (RR 1.60; 95% CI 0.87-2.94).
  • Diabetes mellitus was not significantly associated with increased risk of all-cause mortality (RR 0.90; 95% CI 0.61-1.32).
  • Diabetes mellitus significantly increased the long-term risk of target-vessel restenosis by 210% (RR 2.10; 95% CI 1.18-3.73).

Sources:

  • "Influence of Diabetes Mellitus on Outcomes of Patients Undergoing Carotid Artery Stenting: A Systematic Review and Meta-Analysis." Annals of Vascular Surgery, vol. 122, 2025, pp. 635-645.
  • San Raffaele University.
  • Eren Cetinel, Rafael Andrade, Mostafa Labib, Andressa Frankowski Dagostin, Ghislain Irakoze Habiyambere, Him Shun Kei, and Dario Madera.

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